Irresistible Spicy Southern Chicken Spaghetti Casserole

Highlighted under: Comfort Food

Savor the vibrant flavors of the South with this Irresistible Spicy Southern Chicken Spaghetti Casserole. Packed with tender chicken, a creamy and zesty sauce, and just the right amount of kick, this dish is a comforting blend of pasta and spice that will warm your heart and please your palate. Perfect for family dinners or potluck gatherings, this casserole is sure to become a new favorite in your recipe collection.

Imogen Price

Created by

Imogen Price

Last updated on 2025-12-01T16:43:03.558Z

This casserole combines the heartiness of chicken and pasta with a flavorful, spicy sauce that embodies the essence of Southern cooking.

A Southern Classic with a Twist

The Southern Chicken Spaghetti Casserole is a beloved dish that combines traditional Southern comfort food with a spicy kick. This casserole not only satisfies your hunger but also infuses your meal with rich, vibrant flavors that are characteristic of Southern cuisine. Imagine a warm, bubbling dish that brings together the heartiness of chicken, the creaminess of a cheese sauce, and the zest of spices, making it an unforgettable meal for family and friends.

What sets this dish apart is its flexibility. While it adheres to the classic roots of Southern cooking, you can easily customize the flavors to suit your palate. Want it spicier? Add more cayenne or throw in some diced jalapeños. Prefer a different protein? Swap the chicken for turkey or even some sautéed vegetables for a vegetarian option. This versatility makes it a perfect candidate for both weeknight dinners and special occasions.

Perfect for Any Gathering

Whether you're preparing for a family dinner, a potluck, or a holiday gathering, this casserole is a fantastic choice. It serves well as a main dish and pairs beautifully with a simple green salad or cornbread. The dish can be prepared ahead of time, allowing the flavors to meld and intensify, making it even more delicious when you finally pop it into the oven. Guests will be pleasantly surprised by the delightful combination of flavors and the comforting warmth it provides.

Not only does this casserole fill bellies, but it also creates an inviting atmosphere around the dinner table. The aroma of spices floating through your home invites conversation and laughter, making mealtime a gathering of love as well as food. With its rich flavors and satisfying texture, it’s sure to please everyone from children to adults.

Storing and Reheating Leftovers

Ingredients

Gather your ingredients before you start cooking!

Ingredients

  • 8 ounces spaghetti
  • 2 cups cooked chicken, shredded
  • 1 can (10.5 ounces) cream of chicken soup
  • 1 cup sour cream
  • 1 cup chicken broth
  • 1 teaspoon cayenne pepper
  • 1 teaspoon paprika
  • 1 cup shredded cheddar cheese
  • 1/2 cup chopped green onions
  • Salt and pepper to taste

Make sure everything is measured and ready for a smooth cooking experience.

Instructions

Follow these steps to create your delicious casserole!

Preheat the Oven

Preheat your oven to 350°F (175°C).

Cook the Spaghetti

In a large pot, cook the spaghetti according to package instructions until al dente. Drain and set aside.

Mix the Casserole Ingredients

In a large mixing bowl, combine the shredded chicken, cream of chicken soup, sour cream, chicken broth, cayenne pepper, paprika, salt, and pepper. Mix well.

Combine with Spaghetti

Add the cooked spaghetti to the chicken mixture and stir to combine.

Transfer to Baking Dish

Transfer the mixture to a greased 9x13 inch baking dish. Sprinkle the cheddar cheese and chopped green onions on top.

Bake

Bake in the preheated oven for 30-40 minutes, or until heated through and bubbly.

Allow to cool slightly before serving. Enjoy!

Nutritional Benefits

This casserole not only offers a burst of flavors but also presents a well-rounded meal option. It's packed with protein from shredded chicken and dairy, providing essential nutrients your body needs. The addition of vegetables can boost the nutritional profile even further by adding fiber and vitamins. With a rich source of calcium from the cheese and cream, this dish can contribute to your daily nutritional needs.

While indulgent, you can modify the recipe to reduce calories by substituting lower-fat options for sour cream and cheese, allowing you to enjoy the rich flavors without adding unnecessary calories. This makes it easier to balance a hearty meal with a nutritious one.

Pairing Suggestions

To complement your Spicy Southern Chicken Spaghetti Casserole, think about serving it with refreshing sides that balance out the dish's richness. A crisp, tangy coleslaw or a simple tossed salad drizzled with a light vinaigrette can add a refreshing contrast. Additionally, some freshly baked garlic bread or cornbread can be wonderful to soak up the creamy sauce without overwhelming your palate.

If you're looking for beverage pairings, consider sweet tea, a classic Southern choice, or a light-bodied white wine such as Pinot Grigio. The slight sweetness of these drinks plays off the spice of the casserole, creating a delightful dining experience that’s sure to please everyone at your table.

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Questions About Recipes

→ Can I use leftover chicken?

Absolutely! Leftover rotisserie chicken works great in this recipe.

→ Can I make this dish ahead of time?

Yes, you can prepare the casserole a day in advance and refrigerate it before baking.

Irresistible Spicy Southern Chicken Spaghetti Casserole

Savor the vibrant flavors of the South with this Irresistible Spicy Southern Chicken Spaghetti Casserole. Packed with tender chicken, a creamy and zesty sauce, and just the right amount of kick, this dish is a comforting blend of pasta and spice that will warm your heart and please your palate. Perfect for family dinners or potluck gatherings, this casserole is sure to become a new favorite in your recipe collection.

Prep Time20 minutes
Cooking Duration40 minutes
Overall Time1 hour

Created by: Imogen Price

Recipe Type: Comfort Food

Skill Level: Intermediate

Final Quantity: 6 servings

What You'll Need

Ingredients

  1. 8 ounces spaghetti
  2. 2 cups cooked chicken, shredded
  3. 1 can (10.5 ounces) cream of chicken soup
  4. 1 cup sour cream
  5. 1 cup chicken broth
  6. 1 teaspoon cayenne pepper
  7. 1 teaspoon paprika
  8. 1 cup shredded cheddar cheese
  9. 1/2 cup chopped green onions
  10. Salt and pepper to taste

How-To Steps

Step 01

Preheat your oven to 350°F (175°C).

Step 02

In a large pot, cook the spaghetti according to package instructions until al dente. Drain and set aside.

Step 03

In a large mixing bowl, combine the shredded chicken, cream of chicken soup, sour cream, chicken broth, cayenne pepper, paprika, salt, and pepper. Mix well.

Step 04

Add the cooked spaghetti to the chicken mixture and stir to combine.

Step 05

Transfer the mixture to a greased 9x13 inch baking dish. Sprinkle the cheddar cheese and chopped green onions on top.

Step 06

Bake in the preheated oven for 30-40 minutes, or until heated through and bubbly.

Nutritional Breakdown (Per Serving)

  • Protein: 30g
  • Carbohydrates: 50g
  • Fat: 20g